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Belous A.A., Otradnov P.I., Romazeva M.E. Genomic evaluation of reproductive traits in large white pigs (Sus scrofa). Sel'skokhozyaistvennaya Biologiya [Agricultural Biology], 2025, Vol. 60, № 6, p. 1005-1018.
(how to cite this article)

doi: 10.15389/agrobiology.2025.6.1005eng

UDC: 636.4:577.2

Acknowledgements:
Carried out within the State Assignment of the Ministry of Science and Higher Education of the Russian Federation No. FGGN-2025-0005

 

GENOMIC EVALUATION OF REPRODUCTIVE TRAITS IN LARGE WHITE PIGS (Sus scrofa)

A.A. Belous1✉, P.I. Otradnov2, M.E. Romazeva2

1All-Russian Research Institute of Integrated Fish Farming — branch of the Ernst Federal Research Center for Animal Husbandry, 24, ul. Sergeeva, r.p. im. Vorovskogo, Noginsk District, Moscow Province, 142460 Russia, e-mail abelous.vij@ya.ru (✉ corresponding author);
2Ernst Federal Research Center for Animal Husbandry, 60, pos. Dubrovitsy, Podolsk District, Moscow Province, 142132 Russia, e-mail romazevamasha12345@gmail.com, deriteronard@gmail.com

ORCID:
Belous A.A. orcid.org/0000-0003-4242-2239
Romazeva M.E. orcid.org/0000-0002-8897-8884
Otradnov P.I. orcid.org/0000-0002-1153-5815

Final revision received May 16, 2025
Accepted August 04, 2025

Litter size is one of the most important economic traits for the pig industry because it is directly related to the efficiency of production of marketable and breeding stock. An important characteristic of litter size in pigs is the number of weaned piglets (NFP). This characteristic shows, in particular, the safety of young pigs from birth to weaning and subsequent rearing. There are also traits characterizing negative aspects of reproduction: piglets born dead (stillborn piglets, MP) and piglets “mummified” during embryonic development (“mummified” fetus, MM). The material of our study was a total of 709 Large White pigs with records of CPC, MR and MM traits. For each trait, genomic estimates of breeding value (GEBV) were calculated, the best individuals were selected and a genome-wide association study (GWAS) was performed. A total of 702 SNP markers (single nucleotide polymorphisms) interrelated with the traits under study were identified, but of interest was the annotation of markers “common” to a number of traits, which resulted in the identification of 27 genes, of which ten promising genes were identified, having relationships with the traits under study and previously found in pigs (Sus scrofa): PSMB1, CLDN3, CLDN4, FAM120B, TCTE3, WDR27, MLXIPL, ELN, PARP14, DTX3L. Functional annotation by biological pathways (GO) was generated for 8 genes related to adipose tissue differentiation (GO:0045444), blood pressure regulation (GO:0008217), spinal cord development (GO:0021510), skeletal muscle tissue size or mass increase (GO:0048630), skeletal muscle tissue development (GO: 0007519), nervous system development (GO:0007399), lipid biosynthesis process (GO:0008610), brain development (GO:0007420), formation of a functional barrier in the skin that limits its permeability (GO:0061436), aortic valve structure formation and organization process (GO:0003180), and male genital development (GO:0001673). This study contributes to the understanding of genetic structure and formation of genomic evaluation on reproductive performance in large white breed pigs, which can have a positive impact on the efficiency of pork production and show economic benefits, as reflected by the method of comprehensive index evaluation of animals.

Keywords: genomic evaluation, reproduction traits, breeding value evaluation, full genome association study, selection index, Large White pigs.

 

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