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Makletsova M.G., Zelenkova G.A., Zelenkov A.P., Chukhryaeva D.S. Prospects for the use of polyamines in poultry farming — а mini review. Sel'skokhozyaistvennaya Biologiya [Agricultural Biology], 2025, Vol. 60, № 4, p. 627-640.
(how to cite this article)

doi: 10.15389/agrobiology.2025.4.627eng

UDC: 636.5:636.084:636.085.13

Acknowledgements:
Supported by the Russian Science Foundation, the project № 24-26-00225, https://rscf.ru/project/24-26-00225/.

 

PROSPECTS FOR THE USE OF POLYAMINES IN POULTRY FARMING — А MINI REVIEW

M.G. Makletsova✉, G.A. Zelenkova, A.P. Zelenkov, D.S. Chukhryaeva

Don State Technical University (DSTU), 1, ploshchad’ Gagarina, Rostov-on-Don, 344003 Russia, e-mail mgm52@bk.ru (✉ corresponding author), galinazelenkova2025@gmail.com, zelenkovalex@rambler.ru, daryachuhraeva@gmail.com

ORCID:
Makletsova M.G. orcid.org/0000-0002-8772-3265
Zelenkov A.P. orcid.org/0000-0002-2212-0375
Zelenkova G.A. orcid.org/0000-0002-8562-4423
Chukhryaeva D.S. orcid.org/0009-0007-2377-2221

Final revision received September 06, 2024
Accepted December 04, 2024

Polyamines are critically important for farm animals and birds in conditions of application of modern intensive breeding technologies and high stress loads. The main representatives of polyamines include putrescine, spermidine and spermine. Performing important physiological functions in avian cells during embryogenesis and further development, they possess pleiotropic biochemical activity, including the regulation of gene expression, cell proliferation and modulation of cell signaling (I.L.M.H. Aye et al., 2022; E. Stolarska et al., 2023; Yu.S. Kolesnikov et al., 2024). Polyamines are necessary for the stabilization of DNA and mRNA during gene transcription and mRNA translation, for stimulation of proliferation and apoptosis during the formation of organs and tissues, and are also involved in the regulation of transport and metabolism of nutrients, vitamins, calcium and other metabolites (U. Bachrach 2005; H.L. Lightfoot et al., 2014; S. Nakanishi et al., 2021). Currently, spermidine is reasonably considered a compound capable of increasing life expectancy, due to its effective effect on cell autophagy and the preservation of telomere length. Polyamines in the body of birds are synthesized from amino acids – arginine and proline. It is known that ornithine is formed under the action of arginase and the limiting enzyme in the biosynthesis of polyamines is ornithine decarboxylase, which forms putrescine (A.E. Pegg et al., 1981). The spermidine and spermine are formed under the action of synthetases. Recently, by introducing 14C labeled amino acids, it was found that proline can participate in the biosynthesis of polyamines (K. Furukawa et al., 2021). The processes of synthesis and decomposition of polyamines are reversible. During the decomposition of spermine and spermidine, acetyl derivatives are formed (E. Stolarska et al., 2023). The sources of polyamines in the body of birds are also feed and intestinal microflora. The introduction of polyamines into the feeding diet of birds has shown effectiveness in terms of survival, growth and development of birds with increased feed conversion (K.T. Smith et al, 2000). The effectiveness of the use of polyamines is shown not only for meat breeds, but also for egg breeds. In geese, it was found that spermidine and putrescine regulate the proliferation of intestinal cells, while having a positive effect on the intestinal microflora and on the activity of digestive enzymes. Dietary putrescine increases egg production, and in chickens affects the quality of eggshell formation and quantitative characteristics of plumage (S.R. Chowdhury et al., 2001). This review highlights some issues of the biochemistry of polyamines in the poultry body. The data on the use of polyamines in the practice of correcting stress-induced pathologies, such as hypoxia, are considered. Polyamines can function as primary stress molecules in bacteria, plants, and animals, including birds (T.T. Berezov et al., 2013; M.G. Makletsova et al., 2022). The physiological effect of polyamines extends to all organ and tissue systems of birds, especially the central nervous system. Spermidine and spermine are modulators of neurotransmitter systems of the brain, which makes them promising drugs for correcting bird behavior, a violation of which is observed under stress, as well as factors for increasing life expectancy. It is obvious that studying the effect of stress on the metabolism of polyamines in poultry tissues will allow correcting stress-induced changes that have a negative impact on the course of poultry development and limits the use of intensive technologies.

Keywords: polyamines, putrescine, spermidine, spermine, poultry farming, birds, chickens, geese, eggshells.

 

REFERENCES

  1. Dolgorukova A.M., Titov V.Yu., Fisinin V.I., Zotov A.A. Prenatal nutrition of poultry and its postnatal effects (review). Sel'skokhozyaistvennaya biologiya [Agricultural Biology],2020, 55(6): 1061-1072 CrossRef
  2. Ribeiro L.N.M., Schlemper A.E., da Silva M.V., Fonseca B.B. Chicken embryo: a useful animal model for drug testing? European Review for Medical and Pharmacological Sciences, 2022, 26(13): 4828-4839 CrossRef
  3. Vlasov E.A., Sizova E.A., Nechitailo K.S., Ryazantseva K.V., Kamirova A.M., Ivanisheva A.P., Shoshin D.E., Musabaeva L.L., Mustafina A.S. Physical and biological methods to improve feed nutrition value (review). Sel'skokhozyaistvennaya biologiya [Agricultural Biology], 2024, 59(3): 411-425 CrossRef
  4. Silachev D.N., Plotnikov E.Yu., Goryunov K.V., Romanov A. Yu., Ploskonos M.V., Dolgushina N. V., Nikolaev A.A., Torov D. B., Sukhikh G.T. Tsitologiya, 2018, 60(3): 164-172 (in Russ.).
  5. Kolesnikov Yu.S., Kretinin S.V., Filepova R., Dobrov P.I., Martinyuk Ya., Kravets V.S. Phytochemistry Reviews, 2024, 23(4): 997-1026 CrossRef (in Russ.).
  6. Aye I.L.M.H, Gong S., Avellino G., Barbagallo R., Gaccioli F., Jenkins B.J., Koulman A., Murray A.J., Charnock-Jones D.S., Smith G.C.S. Placental sex-dependent spermine synthesis regulates trophoblast gene expression through acetyl-CoA metabolism and histone acetylation. Communications Biology, 2022, 5(1): 586 CrossRef
  7. Stolarska E., Paluch-lubawa E., Grabsztunowicz M., Tanwar U., Arasimowicz-Jelonek M., Phanstiel O., Mattoo A., Sobieszczuk-Nowicka E. Polyamines as universal bioregulators across kingdoms and their role in cellular longevity and death. Critical Reviews in Plant Sciences, 2023, 42(6): 364-384 CrossRef
  8. Bachrach U. Naturally occurring polyamines: interaction with macromolecules. Current Protein and Peptide Science,2005, 6(6): 559-566 CrossRef
  9. Lightfoot H.L., Hall J. Endogenous polyamine function — the RNA perspective. Nucleic Acids Research, 2014, 42(18): 11275-11290 CrossRef
  10. Pasini A., Caldarera C.M., Giordano E. Chromatin remodeling by polyamines and polyamine analogs. Amino Acids, 2014, 46(3): 595-603 CrossRef
  11. Nakanishi S., Cleveland J.L. Polyamine homeostasis in development and disease. Medicine Science, 2021, 9(2): 28 CrossRef
  12. Paul S., Kang S.C. Natural polyamine inhibits mouse skin inflammation and macrophage activation. Inflammation Research, 2013, 62(7): 681-688 CrossRef
  13. Zhou S., Gu J., Liu R., Wei S., Wang Q., Shen H., Dai Y., Zhou H., Zhang F., Lu L. Spermine alleviates acute liver injury by inhibiting liver-resident macrophage pro-inflammatory response through ATG5-dependent autophagy. Frontiers Immunology, 2018, 9: 948 CrossRef
  14. Fujisawa S., Kadoma Y. Kinetic evaluation of polyamines as radical scavengers. Anticancer Research, 2005, 25(2A): 965-969.
  15. Smith T.K. Effect of dietary putrescine on whole body growth and polyamine metabolism. Proceedings of the Society for Experimental Biology and Medicine, 1990, 194(4): 332-336 CrossRef
  16. Sarhan S., Dezeure F., Seiler N. Putrescine derivatives as substrates of spermidine synthase. International Journal of Biochemistry, 1987, 19(11): 1037-1047 CrossRef
  17. Furukawa K., He W., Bailey C.A., Bazer F.W., Toyomizu M., Wu G. Polyamine synthesis from arginine and proline in tissues of developing chickens. Amino Acids, 2021, 53(11): 1739-1748 CrossRef
  18. Pegg A.E., Shuttleworth K., Hibasami H. Specificity of mammalian spermidine synthase and spermine synthase. Biochemical Journal, 1981, 197(2): 315-320 CrossRef
  19. Handa A.K., Fatima T., Mattoo A.K. Polyamines: bio-molecules with diverse functions in plant and human health and disease. Frontiers in Chemistry, 2018, 6: 10 CrossRef
  20. Hirano R., Shirasawa H., Kurihara S. Health-promoting effects of dietary polyamines. Med. Sci., 2021, 9(1): 8 CrossRef
  21. Xuan M., Gu X., Li J., Huang D., Xue C., He Y. Polyamines: their significance for maintaining health and contributing to diseases. Cell Commun. Signal, 2023, 21(1): 348 CrossRef
  22. Park M.H., Igarashi K. Polyamines and their metabolites as diagnostic markers of human diseases. Biomolecules and Therapeutics (Seoul), 2013, 21(1): 1-9 CrossRef
  23. Feng Q., Wang H., Shao Y., Xu X. Antizyme inhibitor family: biological and translational research implications. Cell Commun Signal., 2024, 22(1): 11 CrossRef
  24. Lambertos A., Nuñez-Sanchez M.A., López-García C., López-Contreras A.J., Ramos-Molina B., Peñafiel R. Antizyme inhibitor 2-deficient mice exhibit altered brain polyamine levels and reduced locomotor activity. Biomolecules, 2022, 13(1): 14 CrossRef
  25. Ma R., Jiang D., Kang B., Bai L., He H., Chen Z., Yi Z. Molecular cloning and mRNA expression analysis of antizyme inhibitor 1 in the ovarian follicles of the Sichuan white goose. Gene, 2015, 568(1): 55-60 CrossRef
  26. Gao G., Hu S., Zhang K., Wang H., Xie Y., Zhang C., Wu R., Zhao X., Zhang H., Wang Q. Genome-wide gene expression profiles reveal distinct molecular characteristics of the goose granulosa cells. Front Genet., 2021, 12: 786287 CrossRef
  27. Kang B., Wang X., An X., Ji C., Ling W., Qi Y., Li S., Jiang D. Polyamines in ovarian aging and disease. International Journal of Molecular Sciences, 2023, 24(20): 15330 CrossRef
  28. Dever T.E., Ivanov I.P. Roles of polyamines in translation. The Journal of Biological Chemistry, 2018, 293(48): 18719-18729 CrossRef
  29. Gilbreath K.R., Bazer F.W., Satterfield M.C., Wu G. Amino acid nutrition and reproductive performance in ruminants. In: Amino acids in nutrition and health. Advances in experimental medicine and biology, vol. 1285. G. Wu (eds.). Springer, Cham, 2021: 43-61 CrossRef
  30. Zhang Y., Bai J., Cui Z., Li Y., Gao Q., Miao Y., Xiong B. Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging. Nature Aging, 2023, 3: 1372-1386 CrossRef
  31. Ramani D., De Bandt J.P., Cynober L. Aliphatic polyamines in physiology and diseases. Clinical Nutrition, 2014, 33(1): 14-22 CrossRef
  32. Zwighaft Z., Aviram R., Shalev M., Rousso-Noori L., Kraut-Cohen J., Golik M., Brandis A., Reinke H., Aharoni A., Kahana C., Asher G. Circadian clock control by polyamine levels through a mechanism that declines with age. Cell Metabolism, 2015, 22(5): 874-885 CrossRef
  33. Galasso L., Cappella A., Mulè A., Castelli L., Ciorciari A., Stacchiotti A., Montaruli A. Polyamines and physical activity in musculoskeletal diseases: a potential therapeutic challenge. International Journal of Molecular Sciences, 2023, 24(12): 9798 CrossRef
  34. Igarashi K., Kashiwagi K. Modulation of cellular function by polyamines. The International Journal of Biochemistry & Cell Biology, 2010, 42(1): 39-51 CrossRef
  35. Yoshida M., Kashiwagi K., Kawai G., Ishihama A., Igarashi K. Polyamine enhancement of the synthesis of adenylate cyclase at the translational level and the consequential stimulation of the synthesis of the RNA polymerase ς28 subunit. The Journal of Biological Chemistry, 2001, 276(919): 16289-16295 CrossRef
  36. Visvanathan A., Ahmed K., Even-Faitelson L., Lleres D., Bazett-Jones D.P., Lamond A.I. Modulation of higher order chromatin sonformation in mammalian cell nuclei can be mediated by polyamines and divalent cations. PLoS ONE, 2013, 8(6): e67689 CrossRef
  37. Berezov T.T., Makletsova M.G., Syatkin S.P., Fedorova T.N., Rikhireva G.T., Kulikova O.I., Konovalova E.V., Fedorova T.N. Zhurnal nevrologii i psikhiatrii im S.S. Korsakova, 2013, 113(7): 65-70 (in Russ.).
  38. Igarashi K., Kashiwagi K. The functional role of polyamines in eukaryotic cells. The International Journal of Biochemistry & Cell Biology, 2019, 107: 104-115 CrossRef
  39. Jimenez-Gutierrez G.E., Borbolla-Jiménez F.V., Muñoz L.G., Tapia-Guerrero Y.S., Murillo-Melo N.M., Cristóbal-Luna J.M., Leyva-Garcia N., Cordero-Martínez J., Magaña J.J. The molecular role of polyamines in age-related diseases: an update. International Journal of Molecular Sciences, 2023, 24(22): 16469 CrossRef
  40. Wang X., Ikeguchi Y., McCloskey D.E., Nelson P., Pegg A.E. Spermine synthesis is required for normal viability, growth, and fertility in the mouse. The Journal of Biological Chemistry, 2004, 279(49): 51370-51375 CrossRef
  41. Makletsova M.G., Rikhireva G.T., Kirichenko E.Yu., Trinitatskiy I.Yu., Vakulenko M.Yu., Ermakov A.M. Neyrokhimiya, 2022, 39(3): 265-278 CrossRef (in Russ.).
  42. Eisenberg T., Knauer H., Schauer A., Büttner S., Ruckenstuhl C., Carmona-Gutierrez D., Ring J., Schroeder S., Magnes C., Antonacci L., Fussi H., Deszcz L., Hartl R., Schraml E., Criollo A., Megalou E., Weiskopf D., Laun P., Heeren G., Breitenbach M., Grubeck-Loebenstein B., Herker E., Fahrenkrog B., Fröhlich K.-U., Sinner F., Tavernarakis N., Minois N., Kroemer G., Madeo F. Induction of autophagy by spermidine promotes longevity. Nature Cell Biology, 2009, 11(11): 1305-1314 CrossRef
  43. Nilsson B.O., Persson L. Beneficial effects of spermidine on cardiovascular health and longevity suggest a cell type-specific import of polyamines by cardiomyocytes. Biochemical Society Transactions, 2019, 47(1): 265-272 CrossRef
  44. Wirth A., Wolf B., Huang C.-K., Glage S., Hofer S.J., Bankstahl M., Bär C., Thum T., Kahl K.G., Sigrist S.J., Madeo F., Bankstahl J.P., Ponimaskin E. Novel aspects of age-protection by spermidine supplementation are associated with preserved telomere length. GeroScience, 2021, 43(2): 673-690 CrossRef
  45. Minois N., Carmona-Gutierrez D., Madeo F. Polyamines in aging and disease. Aging, 2011, 3(8): 716-732 CrossRef
  46. Lenis Y.Y., Elmetwally M.A., Maldonado-Estrada J.G., Bazer F.W. Physiological importance of polyamines. Zygote, 2017, 25(3): 244-255 CrossRef
  47. Ishii I., Ikeguchi Y., Mano H., Wada M., Pegg A.E., Shirahata A. Polyamine metabolism is involved in adipogenesis of 3T3-L1 cells. Amino Acids, 2012, 42(2-3): 619-626 CrossRef
  48. Brenner S., Bercovich Z., Feiler Y., Keshet R., Kahana C. Dual regulatory role of polyamines in adipogenesis. The Journal of Biological Chemistry, 2015, 290(45): 27384-27392 CrossRef
  49. Korzun I.A., Neborak E.V., Syatkin S.P., Sungrapova K.Yu., Khilyal’ Abdulla, Ibragimova A.M. Mediko-farmatsevticheskiy zhurnal «Pul’s», 2000, 22(1): 47-54 CrossRef (in Russ.).
  50. Patel A.R., Wang J.Y. Polyamines modulate transcription but not posttranscription of c-myc and c-jun in IEC-6 cells. American Journal of Physiology-Cell Physiology, 1997, 273(3): C1020-C1029 CrossRef
  51. Patel A.R., Wang J.Y. Polyamine depletion is associated with an increase in JunD/AP-1 activity in small intestinal crypt cells. American Journal of Physiology-Gastrointestinal and Liver Physiology, 1999, 276(2): G441-G450 CrossRef
  52. Bachrach U., Wang Y.C., Tabib A. Polyamines: new cues in cellular signal transduction. News in Physiological Sciences, 2001, 16(3): 106-109 CrossRef
  53. Kang B., Xu Q., Chen Z., Wu Y., Yang S., Yang X., Zhang Z., Jiang D. Characterization of goose SPMS: Molecular characterization and expression profiling of SPMS in the goose ovary. Reproductive Biology, 2018, 18(1): 60-65 CrossRef
  54. Liu Y., Zhang X., Yao Y., Huang X., Li C., Deng P., Jiang G., Dai Q. The effect of epigallocatechin gallate on laying performance, egg quality, immune status, antioxidant capacity, and hepatic metabolome of laying ducks reared in high temperature condition. The Veterinary Quarterly, 2023, 43(1): 1-11 CrossRef
  55. Jiang D., Sun Q., Jiang Y., Zhou X., Kang L., Wang Z., Wang X., An X., Ji C., Ling W., Wang Y., Yang Y., Kang B. Effects of exogenous spermidine on autophagy and antioxidant capacity in ovaries and granulosa cells of Sichuan white geese. Journal of Animal Science, 2023, 101: skad301 CrossRef
  56. Qi Q., Hu C., Zhang H., Sun R., Liu Q., Ouyang K., Xie Y., Li X., Wu W., Liu Y., Zhao G., Wei L. Dietary supplementation with putrescine improves growth performance and meat quality of Wenchang chickens. Animals, 2023, 13(9): 1564 CrossRef
  57. Hashemi S.M., Loh T.C., Foo H.L., Zulkifli I., Hair-Bejo M. Dietary putrescine effects on performance parameters, nutrient digestibility, intestinal morphology and tissue polyamine content of broilers fed low protein diet. Iranian Journal of Veterinary Research, 2014, 15(4): 385-391.
  58. Smith T.K., Tapia-Salazar M., Cruz-Suarez L.E., Ricque-Marie D. Feed-borne biogenic amines: natural toxicants or growth promotors? In: Avances en Nutrición Acuícola V. Memorias del V Simposium Internacional de Nutrición Acuícola. L.E. Cruz-Suárez, D. Ricque-Marie, M. Tapia-Salazar, M.A. Olvera-Novoa, R. y Civera-Cerecedo (eds.). Mérida, Yucatán, Mexico, 2000.
  59. Hou L., Gu T., Weng K., Zhang Y., Zhang Y., Chen G., Xu Q. Effects of oxidative stress on the autophagy and apoptosis of granulosa cells in broody geese. International Journal of Molecular Sciences, 2023, 24(3): 2154 CrossRef
  60. Zheng Y., Qiu Y., Wang Q., Gao M., Cao Z., Luan X. ADPN regulates oxidative stress-induced follicular atresia in geese by modulating granulosa cell apoptosis and autophagy. International Journal of Molecular Sciences, 2024, 25(10): 5400 CrossRef
  61. Jiang D., Niu C., Mo G., Wang X., Sun Q., An X., Ji C., Ling W., Li L., Zhao H., Han C., Liu H., Hu J., Kang B. Ferritin heavy chain participated in ameliorating 3-nitropropionic acid-induced oxidative stress and apoptosis of goose follicular granulosa cells. Poultry Science,2023, 102(5): 102606 CrossRef
  62. Jiang D., Ji C., Zhou X., Wang Z., Sun Q., Wang X., An X., Ling W., Kang B. Pathway analysis of spermidine anti-oxidative stress and inducing autophagy in granulosa cells of Sichuan white geese. Theriogenology, 2024, 215: 290-301 CrossRef
  63. Kazaev K.A., Kholodilina T.N., Sizova E.A., Lebedev S.V., Salnikova E.V. Calcium: physiological role, sources and doses in diets of commercial poultry (review). Sel'skokhozyaistvennaya biologiya [Agricultural Biology], 2024, 59(2): 237-257 CrossRef
  64. Chowdhury S.R., Smith N.K. Effects of dietary 1,4-diaminobutane (putrescine) on eggshell quality and laying performance of hens laying thin-shelled eggs. Poultry Science, 2001, 80(12): 1702-1709 CrossRef
  65. Shinki T., Tanaka H., Takito J., Yamaguchi A., Nakamura Y., Yoshiki S., Suda T. Putrescine is involved in the vitamin D action in chick intestine. Gastroenterology, 1991, 100(1): 113-122 CrossRef
  66. Stabellini G., Pellati A., Tosi L., Caruso A., Carinci P. Exogenous spermidine modulates glycosaminoglycan accumulation and epithelial differentiation in chick embryonic skin. The Journal of Experimental Zoology, 1998, 281(6): 594-601 CrossRef
  67. Harrold D., Saunders R., Bailey J. Dietary putrescine supplementation reduces faecal abundance of Clostridium perfringens and markers of inflammation in captive azure-winged magpies.Journal of Zoo and Aquarium Research, 2020, 8(2): 114-123 CrossRef
  68. Landau G., Ran A., Bercovich Z., Feldmesser E., Horn-Saban S., Korkotian E., Jacob-Hirsh J., Rechavi G., Ron D., Kahana C. Expression profiling and biochemical analysis suggest stress response as a potential mechanism inhibiting proliferation of polyamine-depleted cells. The Journal of biological chemistry, 2012, 287(43): 35825-35837 CrossRef
  69. Dienel G.A., Cruz N.F. Induction of brain ornithine decarboxylase during recovery from metabolic, mechanical, thermal, or chememical injary. Journal of Neurochemistry, 1984, 42(4): 1053-1061 CrossRef
  70. Rhee H.J., Kim E.-J., Lee J.K. Physiological polyamines: simple primordial stress molecules. Journal of Cellular and Molecular Medicine, 2007, 11(4): 685-703 CrossRef
  71. Thomas T., Thomas T.J. Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications. Cellular and Molecular Life Sciences, 2001, 58(2): 244-258 CrossRef
  72. Gilad G.M., Gilad V.H. Overview of the brain polyamine-stress-response: regulation, development, and modulation by lithium and role in cell survival. Cellular and Molecular Neurobiology, 2003, 23(4-5): 637-649 CrossRef
  73. Hussain T., Tan B., Ren W., Rahu N., Dad R., Kalhoro D.H., Yin Y. Polyamines: therapeutic perspectives in oxidative stress and inflammatory diseases. Amino Acids, 2017, 49(9): 1457-1468 CrossRef
  74. Polis B., Karasik D., Samson A.O. Alzheimer's disease as a chronic maladaptive polyamine stress response.Aging (Albany NY), 2021, 13(7): 10770-10795 CrossRef
  75. Berezov T.T., Makletsova M.G., Fedorova T.N. Annali klinicheskoy i eksperimental’noy nevrologii, 2012, 6(2), 38-43 (in Russ.).
  76. Makletsova M.G., Fedorova T.N. Zhivie i biokosnie sistemi, 2016, 17 (in Russ.).
  77. Skachkov S.N., Antonov S.M., Iton M.Dzh. Biologicheskie membrani, 2016, 33(1): 3-31 CrossRef (in Russ.).
  78. Kaplan S., Onger M.E., Altunkaynak B. Z., Elibol E., Deniz O.G., Karayigit M. O., Yarım M., Marangoz C., Ragbetli M.C. Effects of spermine and the passive avoidance learning (PAL) following cerebral ischemia in chicks: association with neuroprotection of pyramidal cells. Journal of Chemical Neuroanatomy, 2018, 88: 41-45 CrossRef

 

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